Geno2pheno [coreceptor-hiv2] 1.0

On submitting a sequence containing the V3 region of the HIV-2 envelope protein gp105 below, you will obtain a sequence alignment to the reference strain Mac239 (M33262) and a prediction whether the corresponding virus is capable of using CXCR4 as a coreceptor (R5/X4 or X4 variants) or not (R5 variants).

1. Identifier (optional)	Do not use patient names!
2. Cutoff	Please select the FPR cutoff for the detection of CXCR4 usage. – please select – Optimized cutoff (FPR = 5%) Cutoff at FPR = 1% Cutoff at FPR = 2.5% Cutoff at FPR = 5% Cutoff at FPR = 10% Cutoff at FPR = 15% Cutoff at FPR = 20% The FPR (false positive rate) is the probability of incorrectly classifying an R5 virus as X4-capable. [Help] No clinical recommendations for setting the FPR cutoff in genoytpic prediction of HIV-2 coreceptor usage exist yet.
3. V3 Sequence	upload from file (sequences in FASTA format, or single plain or FASTA sequence): or paste in:
4. Action	Align and Predict Reset (Clear Session) Load sample sequences Switch to vertical layout

---

You will make prediction № 1633. Service started October 13, 2015.